Music in epilepsy: Predicting the effects of the unpredictable

Epilepsy is the most common serious neurological disorder in world. Despite medical and surgical treatment, many individuals continue to have seizures, suggesting adjunctive management strategies are required. Promising effects of daily listening Mozart K.448 on reducing seizure frequency with epilepsy been demonstrated. In our recent randomized control study, we reported positive effect seizures compared a piece an identical power spectrum yet devoid rhythmic structure. promising epilepsy, mechanism(s) underlying such largely unknown. this paper, specifically review how auditory stimulation alters brain dynamics, addition computational approaches define structural features classical music, then propose plausible mechanism for anti-convulsant K.448. We evidence demonstrating that some pieces compositions from other composers as Joplin contain less predictable structure comparison Beethoven. through both entrainment 1/f resonance mechanisms musical containing least structure, might reduce self similarity activity which turn modulates low power, situating more “noise like” state away dynamics can lead seizures.